Over the years, Atop Pharma Solution’s toxicologists have developed and yielded high-quality PDE/NOAEL reports in adherence with the EMA, ISPE, ASTM, and other country-specific guidelines. We have developed PDE/NOAEL reports for oral, parenteral, inhalation, topical, and some of the unique ways, like, ophthalmic and otic. The PDE denotes a substance-specific dose that is improbable to cause an adverse effect if an individual is exposed at or below this dose daily. The no observed adverse effect level (NOAEL) is the highest dose where the effects are marked in the treated group do not indicate an adverse effect to the subject. The NOAEL also described determining the toxicity of a substance or material. We at Atop Pharma Solutions assist you to calculate PDE and NOAEL reports with our toxicologist’s help.