The correct calculation of the cleaning validation limits from maximum allowable carryover (MACO) of a marker compound to the subsequent product is critical for the integrity and triumph of the cleaning validation. However, the process of generating those limits often affects error-prone manual calculations. At Atop Pharma Solutions, we represent a creative yet simple tool that uses software and a statistical platform to fully automate MACO calculations in pharmaceutical cleaning validation. A reliable cleaning validation program is important to GMP manufacturing and benefits allow a manufacturing unit to deliver quality products on time and in full to market. This program along with other quality programs such as process validation, corrective and preventive action (CAPA) has shown significant results.