A systematic review that assumes only the favorable outcomes of an intervention, without considering the adverse effects can delude by a bias favoring the intervention. Systematic literature searching is identified as a critical element of the systematic review process. Readers need to be able to remember how strategic choices made in the review process decide what damages are found and how the findings may affect clinical decisions. Researchers launching a systematic review that incorporates adverse effect data should understand the grounds for the suggested methods. Atop Pharma Solutions directs you to the Population, Intervention, Comparison and Outcomes (PICO) method in a search, and you can quickly develop a progressive query to explore deeply. We help you build your risk assessment on better data from the literature and regulatory documents. We design more practical trials of historical precedents of adverse events. We also compare your drug candidate to approved drugs and monitor the post-market interpretation.